Influence of physical and radiobiological models on evaluation of radiotherapy treatment fractionation schedules for GBM brain tumours

This study aims to evaluate the radiotherapy planning performance considering clinical results of glioblastoma multiforme (GBM)-treated patients from both physical and radiobiological perspectives. Radiotherapy plans are done for 20 with GBM tumors who have received radical VMAT treatment on Eclipse-13.5. Dosimetric evaluation metrics estimated compare two in terms TCP, NTCP, P+ context evaluated metrics. Both conventional hypofractionation give better dose homogeneity conformity tumour. In addition, schedule coverage targets cells radiation doses higher than schemes. However, schedules at acceptable safe levels. Statistically, calculated showed good significance between hypofractionated schedules. The led use that can be extended different tumours, which helps breaking down waiting list many hospitals, especially cases pandemics such as COVID-19.